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Azaspiro derivatives (4,5) substituted dean
专利权人:
Grünenthal GmbH
发明人:
WEGERT, Anita,NOLTE, Bert,LINZ, Klaus,HARLFINGER, Stephanie,KÖGEL, Babette-Yvonne,RATCLIFFE, Paul,THEIL, Fritz,GRÖGER, Olga,BRAUN, Birgit
申请号:
ES15737988
公开号:
ES2680820T3
申请日:
2015.07.14
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of the general formula (1) ** Formula ** where Y1, Y1 ', Y2, Y2', Y3, Y3 ', Y4 and Y4' in each case are independently selected from each other from the group consisting of - H, -F, -Cl, -Br, -I, -CN, -NO2, -CHO, -R0, -C (>; = O) R0, -C (>; = O) H, -C (>; = O ) -OH, -C (>; = O) OR0, -C (>; = O) NH2, -C (>; = O) NHR0, - C (>; = O) N (R0) 2, -OH, -OR0, -OC (>; = O) H, -OC (>; = O) R0, -OC (>; = O) OR0, -OC (>; = O) NHR0, -OC (>; = O) N (R0) 2, - SH, -SR0, -SO3H, - S (>; = O) 1-2-R0, -S (>; = O) 1-2NH2, -NH2, -NHR0, -N (R0) 2, -N + (R0) 3, -N + (R0) 2O-, -NHC (>; = O) R0, -NHC (>; = O) OR0, -NHC (>; = O) NH2, - NHC (>; = O) NHR0 and -NHC (>; = O) N (R0) 2; or Y1 and Y1 ', or Y2 and Y2', or Y3 and Y3 ', or Y4 and Y4' together represent>; = O; X1, X1 ', X2, X2', X3 and X3 'in each case independently represent each other -H, -F, -Cl, -Br, -I, -NO2, -CF3, -OR5, - SR5, -SO2R5 , -S (>; = O) 2OR5, -CN, -COOR5, -CONR5, -NR6R7, or -R0; or X1 and X1 ', or X2 and X2', or X3 and X3 'together represent>; = O; or X1 and X2, or X2 and X3 together represent - (CH2) 2-6-, where the individual hydrogen atoms can also be substituted by -F, -Cl, -Br, -I, -NO2, -CF3, - OR5, -CN or -C1-6-aliphatic; or X1 and X1 ', or X2 and X2' or X3 and X3 'together represent a C3-6-cycloaliphatic, where individual hydrogen atoms can also be substituted by -F, -Cl, -Br, -I, -NO2 , -CF3, -OR5, -CN or -C1-6-aliphatic; R0 in each case independently represents -C1-8-aliphatic, -C3-12-cycloaliphatic, -aryl, -heteroaryl, -C1-8-aliphatic-C3-12-cycloaliphatic, -C1-8-aliphatic-aryl, -C1 -8-aliphatic-heteroaryl, -C3-8-cycloaliphatic-C1-8-aliphatic, -C3-8-cycloaliphaticaryl or -C3-8-cycloaliphatic-heteroaryl; R1 and R2 independently represent each other -H or -R0; or R1 and R2 together represent -CH2CH2OCH2CH2-, -CH2CH2NR8CH2CH2- or - (CH2) 3-6-; R3 represents -R0; R4 represents H or -Z-R11, where Z may be absent or -C (>; = O) -, -S (>; = O) - or -S (>; = O
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