Ryan DeSousa,Nissanke L. Dassanayake,Howard Allen Ketelson
申请号：
US12536141
公开号：
US08093352B2
申请日:
2009.08.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed are polyquaternary ammonium polymers containing polyalkylene oxide groups according to formula (I) wherein [A]x, [B]y and [C]z are poly(alkylene oxides) each independently selected from the group consisting of poly(ethylene oxide), poly(propylene oxide), and poly(butylene oxide) Z is selected from the group consisting of —CH2CH═CHCH2—, —CH2CH2CH2CH2—, —CH2—C≡C—CH2—, —CH2CH2—O—CH2CH2—, —CH2—N(CH2CH2)2N—CH2—, —CH2CH(OH)CH(OH)CH2— and —CH2—C6H4—CH2— R is —(CR1R2)mCR3R4— wherein m is an integer from 0 to 3 and R1, R2, R3 and R4 are independently selected from the group consisting of H, CH3 and CH2CH3 n is an integer from 1 to 30 x is either 0 or an integer from 2 to 20 y is an integer from 2 to 20 z is either 0 or an integer from 2 to 20 R′ is a branched or unbranched alkyl group having from 1 to 3 carbon atoms and is optionally substituted by one or two hydroxyl groups Q1 and Q2 are independently selected from the group consisting of —CH2CH═CHCH2—X, —CH2C≡C—CH2—X, —N(R′)2, —N(R′)3, —N(R′)(R″), and —N(R′)2(R″), wherein X is a halogen atom and R″ is a benzyl group and a stoichiometric amount of a pharmaceutically acceptable anion. Also disclosed are suitable methods of making the polymers, and methods of using the polymers.
