A system automatically calculates optimal protocol parameters for dark-blood (DB) preparation and inversion recovery. The system automatically determines pulse sequence timing parameters for MR imaging with blood related signal suppression. The system comprises an acquisition processor for acquiring data indicating a patient heart rate. A pulse timing processor automatically determines an acquisition time of an image data set readout, relative to a blood signal suppression related magnetization preparation pulse sequence, by calculating the acquisition time in response to inputs including, (a) the acquired patient heart rate, (b) data indicating a type of image contrast of the pulse sequence employed and (c) data indicating whether an anatomical signal suppression related magnetization preparation pulse sequence used has a slice selective, or non-slice selective, data acquisition readout.