A fastener system comprising a strap incorporating a plurality of teeth and comprising a buckle incorporating a plurality of slots. The strap can be engaged by the buckle such that the strap resists disengagement by a separating force applied generally equally across the width of the strap and the buckle, but will disengage upon application of an asymmetrical force applied proximate either just to the top edge or just to the bottom edge of the buckle and strap. The fastener system can be associated with a cuff or other article so as to releasably maintain two opposing side edges of the cuff in proximity to each other.