Terrence R. Burke, Jr.,Fa Liu,Kyung S. Lee,Jung-Eun Park
申请号：
US13320726
公开号：
US09175038B2
申请日:
2010.05.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Found in various eukaryotic organisms, polo-like kinases (collectively, Plks) are a conserved subfamily of Ser/Thr protein kinases that play critical roles in cell proliferation. Provided herein are compounds that specifically inhibit the activity of Plks, specifically Plk1. Further provided herein are methods for use of the compounds for the treatment of hyperproliferative disorders, particularly cancer. Also provided are uses of the compounds for the preparation of a medicament.
