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ARYL AND HETEROARYLETHYLACTYLGUANIDINE, PREPARING AND USING THEM IN THERAPY
专利权人:
SANOFI-AVENTIS
发明人:
BOChKEI Jozhef Zholt (FR),БОЧКЕИ Йожеф Жолт (FR),MakKORT Gari (FR),МакКОРТ Гари (FR),T'ER Beranzher (FR),ТЬЕР Беранжер (FR),MATTER Khans (FR),МАТТЕР Ханс (FR),ShTAJNKhAGEN Khenning (DE),ШТАЙНХАГЕН Хен,BOCHKEI JOZHEF ZHOLT,MAKKORT GARI,TER BERANZHER,MATTER KHANS,SHTAJNKHAGEN KHENNING,ШТАЙНХАГЕН Хеннинг (DE)
申请号:
RU2009101050/04
公开号:
RU0002446165C2
申请日:
2007.06.13
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a compound of formula (I)wherein: A means a ring selected from phenyl group or heteroaryl group, Q means oxygen atom or a link -CH2-, X, Y and Z mean carbon atoms; R1 and R2, identical or different are selected from the following atoms and groups: hydrogen, halogen, -CF3, (C1-C6)alkyl, Alk, (C1-C6)alkoxy, (C1-C6)alkyl-O-(C1-C6)alkyl, -(CH2)m-SO2-(C1-C6)alkyl with m equal to 0, 1 or 2, benzyl, pyrazolyl, -CH2-triazolyl and -L-R12 wherein L represents a link or a bridge -CH2- and/or -CO- and/or -SO2-, and R12 means (C3-C8)cycloalkyl or group of formula ,wherein: n=0 or 1, R13 means one-three groups, identical or different, selected from hydrogen atom and hydroxyl, (C1-C4)alkyl, oxo and phenyl, R14 means hydrogen atom or is selected from groups - NR18R19, -NR18-COOR19, -NR18-Alk-R20 and -R21, wherein R18, R19, R20, R21 and Alk have the values as specified below, R14' means -CO-(C1-C6)alkyl, R15 is selected from groups -Alk, -R20, -Alk-R20, -Alk-R21, -CO-Alk, -CO-R20, -CO-R21, -Alk-CO-NR18R19, (C3-C8)cycloalkyl and -CO-(C3-C8)cycloalkyl, wherein R18, R19, R20, R21 and Alk has the values as specified below, R16 means hydrogen atom or group Alk, wherein Alk has the values as specified below, R17 means group -Alk, -Alk-R20 or -Alk-R21, wherein Alk, R20 and R21 have the values as specified below, -CO-(C1-C6)alkyl, -CO-(C3-C8)cycloalkyl, R18 and R19, identical or different, mean hydrogen atom or (C1-C6)alkyl, R20 means phenyl or heteroaryl group (such as pyridinyl, pyrazolyl, pyrimidinyl or benzimidazolyl), which is optionally substituted by one (C1-C6)alkyl, R21 means heterocycloalkyl group optionally substituted by one or more halogen atoms or (C1-C6)alkyl, hydroxyl or (C1-C4)alkoxy groups, and Alk means (C1-C6)alkyl which is linear or branched and which is optionally substituted by one or two groups, identical or different, selected from hydroxyl, phenyl, (C1-C4)alkoxy and -NR18R19, wherein R18 and R19 have the
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