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CYSTEINE ENGINEERED ANTIBODIES AND CONJUGATES
专利权人:
Genentech; Inc.
发明人:
Sunil Bhakta,Jagath R. Junutula
申请号:
US14185080
公开号:
US20140288280A1
申请日:
2014.02.20
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody. Certain highly reactive cysteine engineered antibodies were identified by the PHESELECTOR assay. Isolated cysteine engineered antibodies may be covalently attached to a capture label, a detection label, a drug moiety, or a solid support.
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