SULFATE DE CHONDROÏTINE SULFATÉE BIOTECHNOLOGIQUE À LA POSITION 4 OU 6 SUR LA MÊME CHAÎNE DE POLYSACCHARIDE, ET PROCÉDÉ POUR LA PRÉPARATION DE CELUI-CI

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专利权人:

Gnosis S.p.A.

发明人:

申请号：

EP12725644.4

公开号：

EP2707396B1

申请日:

2012.05.10

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

The present invention discloses a process for the production of chondroitin sulphate with an average molecular weight (Mw) of 10-30 kDa by chemical sulphation starting from an unsulphated chondroitin backbone, obtained in turn by acid hydrolysis of capsular polysaccharide K4 made directly from E. coli strain O5:K4:H4, or directly produced from a genetically modified strain of E. coli. Sulphation of the N-acetyl-D-galactosamine residue at position 4 or 6 takes place simultaneously in the same polysaccharide chain, simulating the sulphation pattern observed in natural chondroitin sulphate, unlike the sulphation obtained with the synthesis methods described to date.

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