METHODS AND USES FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES

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专利权人:

Inc.;NGM Biopharmaceuticals

发明人:

Lei LING,Hui TIAN

申请号：

US16600139

公开号：

US20200197489A1

申请日:

2019.10.11

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Provided herein are methods of modulating bile acid homeostasis or treating a bile-acid related or associated disorder, comprising using variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics), in combination with agents effective in modulating bile acid homeostasis or treating a bile-acid related or associated disorder.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/