Martine Petronella Bos,Jan Poolman,Boris Tefson,Johannes Petrus Maria Tommassen
申请号：
US13211977
公开号：
US08163295B2
申请日:
2011.08.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally down-regulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
