Fred Hutchinson Cancer Research Center;HUTCHINSON FRED CANCER RES
发明人:
申请号：
EP12848741.0
公开号：
EP2776451B1
申请日:
2012.11.09
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Compositions and methods are provided for eliciting antigen-specific T-cell responses against human cyclin A1 (CCNA1), which is herein identified as a leukemia-associated antigen based on its overexpression in acute myeloid leukemia (AML) including leukemia stem cells (LSC) and in immunologically privileged testis cells, but not in other normal cell types. CCNA1-derived peptide epitopes that are immunogenic for T-cells including CTL are disclosed, as are immunotherapeutic approaches using such peptides for vaccines and generation of adoptive transfer therapeutic cells.
