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PIPERIDINE DERIVATIVES AS GPR119 AGONISTS
专利权人:
ЧХОН КХУН ДАН ФАРМАСЬЮТИКАЛ КОРП. (KR)
发明人:
ЛИ ЧханСик (KR),ЧАН ТэкСу (KR),ЧОЙ ДэКё (KR),КО МуСон (KR),КИМ ДоХун (KR),КИМ СоЮн (KR),МИН ЧеКи (KR),КИМ УСик (KR),ЛИМ ЮнТэ (KR)
申请号:
RU2014142328
公开号:
RU2014142328A
申请日:
2013.06.11
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A piperidine derivative of formula 1, its stereoisomers or pharmaceutically acceptable salts [Formula 1] in which W is an O or N-R group; R, R and R are each independently H or a C alkyl group; R is —F or —C hyperfluoride an alkyl group; R and R are each independently selected from the group consisting of H, halogen, a -C 1-6 alkyl group and a -C 6-6 cycloalkyl group in which the 1-C 1 -alkyl group and the 3-Cycloalkyl group are each independently unsubstituted or substituted with halogen, -CN, -OC 1 -alkyl group, or -C 1-6 alkyl group; or R and R are a combination oval, forming an -cycloalkyl group in which an -cycloalkyl group is unsubstituted or substituted by halogen, an -OCalkyl group or an -alkyl group; selected from the group consisting of in which Rf and RF are each independently H, a halogen, an -alkyl group, an -alkyl ( OH) a group, an —OC alkyl group or —CN group; selected from the group consisting of in which Rk and Rk are each independently H, halogen, —Calkyl group, —Calkyl (OH) group, —OC alkyl group or —CN group; is; Q is an H, —S (O) R group, —S (O) R group, —C (O) R group drinking, -C (O) OR group, -C (O) NHR group, -C (O) NRR group, -S (O) NHR group, -S (O) NRR group or, in which R is H, -CF, -Calkyl group, from A 3- to 7-membered heterocyclic group, a cycloalkyl group, or an Ar group, R and R are each independently a C1-6 alkyl group, a Cycloalkyl group, a 3 to 7-membered heterocyclic group or an Ar group (in R, R and R, a-C1-6 alkyl group, up to a 7-membered heterocyclic group, a cycloalkyl group and Ar can each be independently substituted by Rx and Rx.), or R and R together with the N atoms to which they are bonded can form 5- or a 6 membered heterocyclic aromatic or non-aromatic compound, further including1. Производное пиперидина формулы 1, его стереоизомеры или фармацевтически приемлемые соли[Формула 1]в которомW является О или N-Rгруппой;R, Rи Rкаждая независимо является Н или Cалкильной группой;Rявляется -F или -Cгиперфторид алкильной
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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