Iris Duarte,Maria Jose Pereira,Luis Padrela,Marcio Temtem
申请号：
US15022429
公开号：
US20160228373A1
申请日:
2014.09.16
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention discloses a scalable and solvent-free method to produce cocrystals in a particulate form. A method of making cocrystals comprises the steps of: a) feeding a molten mixture of at least a first substance and a second substance which are able to form cocrystals to an atomizer b) atomizing the molten mixture to droplets c) solidifying the droplets to particles d) collecting the said particles. The invention also provides the use of cocrystals made according to the method of the invention in the formulation of a pharmaceutical composition. The invention also provides cocrystals obtainable or obtained by the method of the present invention, in particular cocrystals in the form of particles. Also provided is a pharmaceutical composition comprising cocrystals made according to the method of the invention, in particular, a pharmaceutical composition comprising cocrystals in the form of particles made according to the method of the invention.
