GUN SUL LEE,JUN SIC KIM,KI HWAN SON,KI-YONG KIM,YONG KANG
申请号：
BR112014009923
公开号：
BR112014009923A2
申请日:
2012.10.24
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Summary Method for Preparation of Highly Concentrated Fibrinogen Solution and Method for Preparation of Fibrin Sealant Using It A method for preparing a highly concentrated fibrinogen solution, and a method for preparing a fibrin sealant component containing the highly concentrated fibrinogen solution and factor? iii. more particularly, the method for preparing a highly concentrated fibrinogen solution according to the present invention may be worked out by adding amino acids or amino acid derivatives, and / or salts, etc., to a weakly concentrated fibrinogen solution separated from the Blood plasma and highly concentrating fibrinogen using an ultrafiltration method, and a fibrin sealant component in order to be used in a fibrin sealant product, may be prepared by addition of factor? iii before or after ultrafiltration in the fibrinogen. method for the preparation of highly concentrated fibrinogen. The fibrin sealant component 1 prepared by the method according to the present invention may be cryopreserved in a liquid state, preserved for a long time at room temperature, and immediately applied to treatment without performing a reconstitution process. furthermore, the present invention relates to a configured fibrin sealant product of the fibrin sealant component 1 and a fibrin sealant component 2, which is a solution containing thrombin and calcium chloride filled in a separate container. The fibrin sealant product according to the present invention may be provided in a vial in which the fibrin sealant component 1 and the fibrin sealant component 2 are filled into separate vials respectively or a pre-filled type. whereas the fibrin sealant component 1 and the fibrin sealant component 2 are filled into separate syringes attached to each other for immediate use.resumo método para preparação de solução de fibrinogênio altamente concentrada e método para preparação de selante de fibrina utilizando o mesmo são fornecidos um método para a preparação de uma solução de fib
