Darwin J. Prockop,Ryang Hwa Lee,Nara Yoon,John Reneau,Barry Berkowitz
申请号:
US14436637
公开号:
US20150272992A1
申请日:
2013.10.17
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A method of treating a tumor in an animal by administering to the animal mesenchymal stem cells that have been contacted with a stimulating, or activating agent, such as TNF-a, that stimulates the mesenchymal stem cells to express increased amounts of at least one agent, such as TRAIL and/or DKK-3, that inhibits, prevents, or destroys the growth of tumors. The stimulated, or activated mesenchymal stem cells may be administered in combination with at least one chemotherapeutic agent, such as doxorubicin.