as represented by the Secretary of the Department of;The Government of the United States of America
发明人:
Che-Hung Robert Lee,Carl E. Frasch
申请号：
US13892163
公开号：
US20130337004A1
申请日:
2013.05.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
