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METHODS OF INDUCING CHONDROGENESIS IN MESENCHYMAL STEM CELLS USING SYNTHETIC TRITERPENOIDS
专利权人:
TRUSTEES OF DARTMOUTH COLLEGE;THE UNITED STATES OF AMERICA, as represented byTHE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE;RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
发明人:
Gordon W. Gribble,Damian Medici,Pamela Gehron Robey,Karen T. Liby,Michael B. Sporn,Nanjoo Suh
申请号:
US14358077
公开号:
US20140328809A1
申请日:
2012.11.14
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention relates to methods for enhancing differentiation of mesenchymal stem cells into chondrocytes and/or inducing chondrogenesis. The invention also relates to applications in the treatment of diseases which can affect cartilage (chondrodystrophies). The present invention also relates to methods of treatment comprising establishing a population of chondrocytes from a population of mesenchymal stem cells, which have been induced to differentiate with a synthetic triterpenoid, and administering the population of cells to a patient.
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