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TOPICAL CORNEAL ANALGESIA USING NEUROTENSIN RECEPTOR AGONISTS AND SYNERGISTIC NEUROTENSIN COMBINATIONS WITHOUT DELAYING WOUND HEALING
专利权人:
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH;SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH;SARENTIS THERAPEUTICS, INC.
发明人:
DENISE BARBUT,Gavril W. Pasternak,Elliott Richelson
申请号:
US14512250
公开号:
US20150273011A1
申请日:
2014.10.10
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A method for administering an ocular analgesic is described. The method includes the steps of providing a topical analgesic that includes a neo-tryptophan-containing neurotensin analog and applying the topical analgesic to the ocular tissue in a dose of about 0.0001 to about 5 mg, alternatively about 0.0001 to about 3 mg, alternatively about 0.0005 to about 1.2 mg, alternatively about 0.0005 to about 1.0 mg, alternatively about 0.00075 to about 1.0 mg, alternatively about 0.001 mg to about 1.0 mg, alternatively about 0.001 mg to about 0.8 mg, alternatively about 0.001 mg to about 0.7 mg, alternatively about 0.001 mg to about 0.6 mg. Methods of administering a topical analgesic containing a neo-tryptophan-containing neurotensin analog are also described. The topical analgesic can be administered in a patch, gel, lotion, spray, or mist.
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