The present invention relates to a pharmaceutical composition comprising a PD-1 antagonist and an M-CSF antagonist. The present combination can be administered independently or separately, in a quantity which is therapeutically effective for the treatment of cancer. The invention also provides the use of such a combination for the manufacture of a medicament; the use of such a combination as a medicine; a kit of part comprising such a combination; and a method of treatment of such a combination.本發明係關於包含PD-1拮抗劑及M-CSF拮抗劑之醫藥組合物。本發明組合可以對於治療癌症治療有效之量獨立地或單獨地投與。本發明亦提供此一組合用於製造藥劑之用途;此一組合作為藥物之用途;包含此一組合之部分之套組;及此一組合之治療方法。