The present invention is directed to novel bifunctional CTI-CTI and CBI-CTI dimers of the formula: F1-L1-T-L2-F2 where F1, L1, T, L2 and F2 are as defined herein, useful for the treatment for proliferative diseases, where the inventive dimers can function as stand-alone drugs, payloads in antibody-drug-conjugates (ADCs), and linker-payload compounds useful in connection with the production or administration of such ADCs and to compositions including the aforementioned dimers, linker-payloads and ADCs, and methods for using these dimers, linker-payloads and ADCs, to treat pathological conditions including cancer.本發明關於新穎的下式之雙官能性CTI-CTI及CBI-CTI二聚物:F1-L1-T-L2-F2其中F1、L1、T、L2和F2係如本文所定義,該等二聚物有用於治療增生性疾病,其中本發明的二聚物可功能作為獨立藥物、抗體藥物共軛體(ADC)的酬載及有用於與此等ADC之製造及投予有關的連接子-酬載化合物;且關於包括前述二聚物、連接子-酬載及ADC之組成物以及使用該等二聚物、連接子-酬載及ADC以治療病理性病狀(包括癌症)之方法。
