FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to formulacompounds and their pharmaceutically acceptable salts, where A represents C(R)； D represents N(R)； E represents N； G are selected from group, consisting of R-O-C(O)- and R-N(R)-C(O)-； Rare selected from hydrogen, halogen and (C-C)-alkyl； Rare selected from (C-C)-alkyl, (C-C) cycloalkyl-CH- and Ar-CH-, where s equals 0, 1, 2 and 3； Rare selected from R-O-, R-N(R)-C(O)-O- and Het-C(O)-O-； Rare selected from hydrogen, R, (C-C)-cycloalkyl and Ar； Rand Rindependently on each other are selected from hydrogen, Rand Ar； Rrepresents (C-C)-alkyl, which is optionally substituted with 1-3 similar or different substituents, selected from halogen, HO-, R-O-, oxo, (C-C)-cycloalkyl, optionally substituted with 1-3 fluorine atoms, Ar, Het, Het, di((C-C)-alkyl)N-C(O)- and Het-C(O)-； Rrepresents (C-C)-alkyl； Rrepresents (C-C)-alkyl, which is optionally substituted with (C-C)-alkyl-O-； Ris selected from group, consisting of R, R-CH- and Het-CH-, where u equals 0； R, Rand Rare such as given in invention formula； Rrepresents hydrogen； Rand Rtogether represent (CH), x equals 2, 3, 4 or 5； Ris selected from group, consisting of hydrogen and HO-； Rrepresents hydrogen； R, Rand Rare such as given in invention formula； Ar is selected from group, consisting of phenyl and aromatic 6-membered monocyclic heterocycle, which includes one nitrogen atom, with phenyl and heterocycle being optionally substituted with 1-3 similar or different substituents, selected from halogen (C-C)-alkyl, optionally substituted with 1-3 fluorine atoms, (C-C)-alkyl-O-, (C-C)-alkyl-S(O)-, HN-S(O)- and NC-； Het, Het, Hetand Hetare such as given in invention formula； m equals 0, 1 and 2. Invention also relates to method of obtaining formula I compounds, pharmaceutical composition and application.EFFECT: formula I compounds, possessing properties of cathepsin A protease.2 cl, 2 tbl, 762 exИзобретение относится к соединениям формулы I и их фармацевтически
