Synthetic metabolites of compounds of Formula (I) salts thereof, prodrugs thereof, pharmaceutical compositions containing such synthetic metabolites, and use of such compound and compositions to treat diseases mediated by raf, VEGFR, PDGFR, p38 and flt-3. Described are M2, M3, M4, and M5 synthetic metabolites of compounds of formula I, wherein the structures of said compound of formula I and said M2, M3, M4, and M5 synthetic metabolites are:Linvention concerne des métabolites synthétiques de composés de formule (I), leurs sels, leurs promédicaments, des compositions pharmaceutiques contenant de tels métabolites synthétiques, et lutilisation de ces composés et compositions dans le traitement de maladies médiées par raf, le VEGFR, le PDGFR, p38 et flt-3.
