HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)
发明人:
Marcus Conrad,Joel Schick,Bettina Proneth,Peter Sennhenn
申请号：
US14904377
公开号：
US09802956B2
申请日:
2014.07.15
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterised by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role. The compounds and pharmaceutical compositions described herein are also useful in the treatment of a condition, disorder or disease that is characterised by oxidative stress or where oxidative stress is likely to play or plays a substantial role； and/or a condition, disorder or disease that is characterised by activation of (1) one or more components of the necrosome； (2) death domain receptors； and/or (3) Toll-like receptors； and/or (4) players in ferroptotic/ferroptosis signalling, or where activation of any one of (1) to (3) and/or (4) is likely to play or plays a substantial role.
