R-SPONDIN ANTAGONISTS AND METHODS OF TREATING CANCER ASSOCIATED WITH ABERRANT ACTIVATION OF WNT SIGNALING

• 收藏
• 分享

专利权人:

发明人:

Calvin J. Kuo,Kelley Yan,Junlei Chang

申请号：

US15134353

公开号：

US20160312207A1

申请日:

2016.04.20

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Compositions and methods for treating cancer associated with aberrant activation of the Wnt signaling pathway are disclosed. In particular, the invention relates to R-spondin antagonists comprising a soluble extracellular domain of ring finger 43 (RNF43) or E3 ubiquitin ligase zinc and ring finger 3 (ZNRF3) and methods of treating cancer with such antagonists.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/