Lee, Jong Seo,Kim, Kyu Tae,Lee, Young Ha,Hwang, In Sik,Ko, Bong Kook
申请号：
AU2017251298
公开号：
AU2017251298A1
申请日:
2017.04.12
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present invention replaces an amino acid residue of a specific region of a parent antibody so as to improve the stability of the antibody, thereby improving druggability. A variant antibody of the present invention, compared to a parent antibody hz1E11, has significantly improved stability while having nearly the same productivity and efficacy. Therefore, the variant antibody of the present invention exhibits, in the development of HER2-specific antibodies, excellent characteristics such as reduction in production costs, inhibition of efficacy reduction and reduction of side effects.
