This invention relates to a composition of antrodia cinnamomea and green algae extract, which is constituted of 30% to 90% of antrodia cinnamomea and 10% to 70% of green algae extract. Since the green algae extract has the advantages that it is easy for liver and kidney to absorb and use, has a stable properties, and can be mixed with any ingredients without conflict, the green algae extract is used as a guiding medicine to greatly increase the efficacy of antrodia cinnamomea absorption by liver and kidney, thereby achieving the objective of enhancing the pharmaceutical efficacy of antrodia cinnamomea. This invention relates to a composition of antrodia cinnamomea and green algae extract, which is constituted of 30% to 90% of antrodia cinnamomea and 10% to 70% of green algae extract. Since the green algae extract has the advantages that it is easy for liver and kidney to absorb and use, has a stable properties, and can be mixed with any ingredients without conflict, the green algae extract is used as a guiding medicine to greatly increase the efficacy of antrodia cinnamomea absorption by liver and kidney, thereby achieving the objective of enhancing the pharmaceutical efficacy of antrodia cinnamomea.