ADMINISTRATION CIBLEE DE GENES A DES CELLULES MAMMIFERES NON PHAGOCYTAIRES PAR L'INTERMEDIAIRE DE MINICELLULES INTACTES DERIVEES DE BACTERIES

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专利权人:

ENGENEIC MOLECULAR DELIVERY PTY LTD.

发明人:

BRAHMBHATT, HIMANSHU,MACDIARMID, JENNIFER

申请号：

CA2549840

公开号：

CA2549840C

申请日:

2004.12.08

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

A method of targeting bacterially-derived, intact minicells to specific, non-phagocytic mammalian cells employs bispecific ligands to deliver nucleic acidsefficiently to the mammalian cells. Bispecific ligands, comprising (i) a firstarm that carries specificity for a bacterially-derived minicell surfacestructure and (ii) a second arm that carries specificity for a non-phagocyticmammalian cell surface receptor are useful for targeting minicells tospecific, non-phagocytic mammalian cells and causing endocytosis of minicellsby non-phagocytic cells.

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