The invention relates to methods, composition and uses for the of treatment of cancer selected from the group consisting of HCC, RCC, NSCLC, ovarian cancer, CCA, PTC and FTC in a subject, which comprise administering an HDAC inhibitor in combination with a compound inhibiting the VEGF/VEGFR interaction, wherein said subject is characterized in having a platelet count of about 140000 platelets/μl or higher.