Disclosed herein is a method for increasing the dendritic spine formation or dendritic spine density in a subject, whom is affected by a dendritic spine defect caused by the impairment in neurofibromin (NF1 protein), valosin-containing protein (VCP), atlastin-1 (ATL1), or superoxide dismutase 1 (SOD1). Accordingly, also disclosed herein is a method for treating a subject having or suspected of having a synaptopathy caused by the impairment inNF1,VCP, ATL1, orSOD1.本揭示內容是關於一種用以增加一個體體內之 樹突棘形成或樹突棘密度的方法,其中該個體係罹患一種因神經纖維瘤蛋白(neurofibromin, NF1)、含纈酪肽蛋白(valosin-containing protein, VCP)、遺傳性痙攣性截癱相關蛋白(atlastin-1, ATL1)或超氧化物歧化酶 1 (superoxide dismutase 1, SOD1)缺失所造成的樹突棘缺損。此外,本揭示內容亦是關於一種用以治療罹患或疑似罹患突觸病變之個體的方法,其中該突觸病變是由NF1、VCP、ATL1或SOD1缺失所造成。
