KUFER, PETER,BERRY, MEERA,OFFNER, SONJA,BRISCHWEIN, KLAUS,WOLF, ANDREAS,RAUM, TOBIAS,KOHLEISEN, BIRGIT,LENKKERI-SCHUTZ, ULLA,BAUERLE, PATRICK
申请号：
CA2522894
公开号：
CA2522894C
申请日:
2004.05.26
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides a pharmaceutical composition comprising abispecific single chain antibody construct. Said bispecific single chainantibody construct is characterized to comprise or consist of at least twodomains, whereby one of said at least two domains specifically binds to humanEpCAM and comprises at least one CDR-H3 region comprising the amino acidsequence NXID antigen and a second domain binds to human CD3 antigen. Theinvention further provides a process for the production of the pharmaceuticalcomposition of the invention, a method for the prevention, treatment oramelioration of a tumorous disease and the use of the disclosed bispecificsingle chain antibody construct and corresponding means in the prevention,treatment or amelioration of a tumorous disease.
