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“TRIAZOLE DERIVATIVE OR SALT THEREOF―
专利权人:
发明人:
YOSHIMURA SEIJI JAPAN,KAWANO NORIYUKI JAPAN,KAWANO TOMOAKI JAPAN,SASUGA DAISUKE JAPAN,KOIKE TAKANORI JAPAN,WATANABE HIDEYUKI JAPAN,FUKUDOME HIROKI JAPAN,SHIRAISHI NOBUYUKI JAPAN,MUNAKATA RYOSUKE JAPAN
申请号:
IN44/MUMNP/2011
公开号:
IN299780B
申请日:
2009.07.02
申请国别(地区):
IN
年份:
2018
代理人:
摘要:
Problem A compound, which can be used for preventing or treating diseases, in which 11²-hydroxysteroid dehydrogenase type 1 (11²-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided. Means for Solution It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with -O- (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11²-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression. EP2298747A1
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中国工程科技知识中心
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