Herman O. Sintim,William E. Bentley,Varnika Roy,Jacqueline Smith,Reza Ghodssi,Mariana Tsacoumis Meyer
申请号：
US13430000
公开号：
US08952192B2
申请日:
2012.03.26
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms.
