LIM, Florencia,TROLLSAS, Mikael,HOSSAINY, Syed Faiyaz,PACETTI, Stephen
申请号：
ES09751163
公开号：
ES2576107T3
申请日:
2009.05.08
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
An implantable device comprising a coating, coating comprising: a reservoir layer comprising a semi-crystalline biodegradable polymer and a primer comprising a biodegradable amorphous polymer, wherein the amorphous polymer has a miscibility of at least 5% in the semicrystalline polymer, where The coating has a degradation or absorption rate so that in a period of 6 months after deployment of the implantable device, the coating has a mass loss of 80% or more, where the semicrystalline polymer is chosen from the group consisting of semi-crystalline poly (L-lactide-co-glycolide) (PLLGA) with L-lactide content ranging from 65% molar to 100% molar, poly (L-lactic acid-co-glycolidene-co-caprolactone) terpolymer (PLLA- GA-CL) semicrystalline with L-lactide content varying from 65% molar or higher, poly (L-lactic acid-co-caprolactone) (PLLA-CL) semicrystalline (L-lactide / CL >； = 75/25 or 70/30 per molar) and combinations thereof, and where the amorphous polymer is chosen from the group consisting of amorphous poly (D, L-lactide) (PDLA), poly (Llactidaco-D, L -lactide) (PLLLA) amorphous with D content, L-lactide 30% molar or higher, poly (D, Llactida-co-glycolide) (PDLGA) amorphous with glycolide content from 10 to 50% molar, poly (L -lactide-coglycolide) (PLLGA) amorphous with L-lactide content of 75% molar or less, amorphous poly (glycolide-co-caprolactone) (PGACL) with glycolide content of 70% molar or less, poly (D, L- amorphous lactide-cocaprolactone) (PDLACL) with caprolactone content of 70% molar or less, amorphous poly (L-lactidacocaprolactone) (PLLACL) with L-lactide content less than 70% molar, but greater than 30% molar, amorphous copolymers of trimethylene carbonate with glycolide, D, L-lactide and / or L-lactide, poly (D, L-lactide-co-glycolide-co-caprolactone) terpolymers (PDLGA-CL) and amorphous PLLA-GA-CL with 65% molar or inf L-lactide content erior and combinations of these.Un dispositivo implantable que comprende un revestimiento, revestimiento que com
