Xiaoqin Cheng,Gary P. Cook,Manoj C. Desai,Edward Doerffler,Gong-Xin He,Choung U. Kim,William A. Lee,John C. Rohloff,Jianying Wang,Zheng-Yu Yang
申请号：
US12436004
公开号：
US08268802B2
申请日:
2009.05.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV,wherein:Y1A and Y1B are independently Y1RX1 and RX2 are independently RXY1 is ═O, —O(RX), ═S, —N(RX), —N(O)(RX), —N(ORX), —N(O)(ORX), or —N(N(RX)(RX))RX is independently R1, R2, R4, W3, or a protecting groupR1 is independently —H or alkyl of 1 to 18 carbon atomsR2 is independently R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R3 groupsR3 is R3a, R3b, R3c or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3c or R3dR3a is —H, —F, —Cl, —Br, —I, —CF3, —CN, N3, —NO2, or —OR4R3b is ═O, —O(R4), ═S, —N(R4), —N(O)(R4), —N(OR4), —N(O)(OR4), or —N(N(R4)(R4))R3c is —R4, —N(R4)(R4), —SR4, —S(O)R4, —S(O)2R4, —S(O)(OR4), —S(O)2(OR4), —OC(R3b)R4, —OC(R3b)OR4, —OC(R3b)(N(R4)(R4)), —SC(R3b)R4, —SC(R3b)OR4, —SC(R3b)(N(R4)(R4)), —N(R4)C(R3b)R4, —N(R4)C(R3b)OR4, —N(R4)C(R3b) (N(R4)(R4)), W3 or —R5W3R3d is —C(R3b)R4, —C(R3b)OR4, —C(R3b)W3, —C(R3b)OW3 or —C(R3b)(N(R4)(R4))R4 is —H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atomsR5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atomsW3 is W4 or W5W4 is R6, —C(R3b)R6, —C(R3b)W5, —SOM2R6, or —SOM2W5, wherein R6 is R4 wherein each R4 is substituted with 0 to 3 R3 groupsW5 is carbocycle or heterocycle wherein W5 is independently substituted with 0 to 3 R2 groups andM2 is 0, 1 or 2and pharmaceutically acceptable salts thereof.
