Feng-Jing Chen,Mahesh V. Patel,David T. Fikstad,Huiping Zhang,Chandrashekar Giliyar
申请号：
US14975488
公开号：
US20160184435A1
申请日:
2015.12.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs are provided. The pharmaceutical compositions include a therapeutically effective amount of a hydrophobic drug, preferably a steroid； a solubilizer, and a surfactant. The synergistic effect between the hydrophobic drug and the solubilizer results in a pharmaceutical formulation with improved dispersion of both the active agent and the solubilizer. As a result of the improved dispersion, the pharmaceutical composition has improved bioavailability upon administration. Methods of improving the bioavailability of hydrophobic drugs administered to a patient are also provided.
