The method, composition and use of the composition for healing defects in boneor cartilage tissue in animals and humans caused by trauma or surgery isdisclosed. The method comprises administration of creatine compounds includinganalogues or pharmaceutically acceptable salts thereof. Treatment inaccordance with this method speeds-up time for and improves the process ofhealing of defects in bone or cartilage tissue in animals and humans caused bytrauma or surgery including acceptance and bonding of artificial implants. Thetreatment with creatine compounds can be therapeutic for diseased patients,preventive for healthy people as well as geriatric for elderly people.
