An antibody that specifically binds to Colony-Stimulating Factor-1 Receptor (CSF-1R). The antibody can comprise a CDR combination selected from: SEQ ID NOs 11-13 and 14-16 SEQ ID NOs 17-19 and 20-22 or SEQ ID NOs 23-25 and 26-28. The antibody can be used for the treatment of cancer, a disease associated with increased osteoclast activity, inflammatory bowel disease or rheumatoid arthritis.