VAN 'T KLOOSTER, Gerben Albert Eleutherius,BRYS, Reginald Christophe Xavier,VAN ROMPAEY, Luc Juliaan Corina,NAMOUR, Florence Sylvie
申请号：
PH12014502615
公开号：
PH12014502615B1
申请日:
2014.11.24
申请国别(地区):
PH
年份:
2015
代理人:
摘要：
The present invention relates to the novel medical use of the compound according to Formula I, in particular in the treatment of inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons. In particular, the compound inhibits JAK a family of tyrosine kinases, and more particularly JAK1. The present invention also provides pharmaceutical compositions comprising the compound, methods for the prophylaxis and/or treatment of diseases involving inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons by administering the compound.
