PURPOSE: A composition using tomato plant extract and Oldenlandia diffusa extract is provided to relieve and detoxify smoking toxicity due to tar and nicotine. CONSTITUTION: A pharmaceutical composition fore detoxifying smoking toxicity contains Oldenlandia diffusa extract as an active ingredient. The Oldenlandia diffusa extract is obtained by dipping Oldenlandia diffusa leaves, stems, flowers, roots, or mixture thereof in 50% ethanol and extracting at 50°;C for 10 hours, and decompressing. The pharmaceutical composition contains one or more among tomato plant extract, Oldenlandia diffusa extract, Sorbus commixta extract, Lithospermum erythrorhizon Sieb extract. and Alnus japonica Steud extract.본 발명은 흡연독성 해독용 약제학적 조성물에 관한 것으로서, 구체적으로는 백화사설초 추출물을 유효성분으로 하는 흡연독성 해독용 약제학적 조성물에 관한 것이다.