The present invention relates to a composition comprising Acorus gramineus and baicalein for the improvement of cognitive function and a manufacturing method of the composition. According to the present invention, the composition comprising Acorus gramineus and baicalein for the improvement of cognitive function comprises: an Acorus gramineus extract obtained by mixing dried Acorus gramineus and water in a weight ratio of 1:12 to 1:8, performing a hydrothermal extraction process at 70-90°；C to get hydrothermal extract, and freeze drying the hydrothermal extract； and baicalein. The composition shows an effect of removing active oxygen species, an antioxidative effect on DNA damage, an inhibitory activity against an angiotensin converting enzyme (ACE), an inhibitory activity against acetylcholine esterase (AChE), an inhibitory activity against the generation of nitric oxide (NO), an activity of increasing the expression of a nitrogen oxide generating enzyme NOS-2, and an effect of increasing the transcriptional activity of NF-&kappa；B in PC12 cells simultaneously.본 발명은 석창포 및 바이칼레인을 포함하는 인지기능 개선 조성물 및 그 제조방법에 관한 것으로, 본 발명에 따른 석창포 및 바이칼레인을 포함하는 인지기능 개선 조성물은 건조된 석창포(Acorus gramineus) 및 물을 1 : 12 내지 1 : 8의 중량비로 혼합하여 70 내지 90℃ 습열추출하고, 상기 습열추출물을 동결건조시킨 석창포 추출물 및 바이칼레인(Baicalein)을 포함하고, 활성산소종의 제거, DNA 손상에 대한 항산화, ACE(Angiotensin Converting Enzyme) 효소 저해활성, AChE(acetylcholine esterase) 저해 활성, NO(Nitric oxide) 생성 억제활성, 산화질소 생성 효소 NOS-2 발현 증가활성 및 PC12세포에서 NF-κB 전사활성 증가효과를 동시에 나타내는 것일 수 있다.
