DERIVADOS DE 2,2-DIFLUOROPROPIONAMIDA DE METIL BARDOXOLONA, FORMAS POLIMORFAS E MÉTODOS DE USO DOS MESMOS

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专利权人:

INC.;REATA PHARMACEUTICALS

发明人:

ERIC ANDERSON,ANDREA DECKER,XIAOFENG LIU

申请号：

PT13720708

公开号：

PT2841445T

申请日:

2013.04.24

申请国别(地区):

PT

年份:

2017

代理人:

摘要：

The present invention relates to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-l,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide and polymorphic forms and pharmaceutical compositions thereof for use in the treatment of cancer in combination with immunotherapy, for use in the treatment of conditions associated with oxidative stree caused by mitochondrial dysfunction and for use in the treatment of seizure disorders.

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