Compositions and methods for the treatment or prevention of an ocular disease in an eye of a patient. The petrolatum-based compositions may include petrolatum and a saline solution comprising at least one cationic biocide. In at least some instances, the compositions do not require the use of an added emulsifier and may contain at least one antiviral agent. Methods of using the petrolatum-based compositions in the treatment of ocular diseases, including infections of the eye are provided. Additionally, processes for preparing such compositions are provided.
