Ltd.;Asclepius (Suzhou) Technology Company Group Co.
发明人:
Huashun LI,Baolei WANG,Kunkun HAN
申请号：
US16700401
公开号：
US20200087397A1
申请日:
2019.12.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to chimeric antigen receptor cells targeting ROBO1, in particular, enhanced CAR-T cells and CAR-NK cells targeting ROBO1, and preparation and application thereof. The cells can stably expressing CAR elements, while secreting extracellular domain molecules expressing PD-1 protein or mutants thereof, and thus may block PD- 11PD-L1 molecular interaction. It has been found through animal experiments that the cells have very good anti-tumor effects, and the above-mentioned cells can significantly reduce tumor recurrence and improve the survival rate compared with the conventional ROBO1-targeted CAR modified cells.
