MASTO, EMILIE,GARRETT, LISA,BARRAT, NIAMH,WONG, YIK TENG,MCLAUGHLIN, ROSALEEN THERESA,BANBURY, SUSAN GERRARD
申请号：
CA3040422
公开号：
CA3040422A1
申请日:
2017.10.13
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Disclosed herein is a solid lyophilized vaginal dosage form that can have an effective amount of at least one active ingredient, a crystalline structure forming agent in an amount of about 5 wt. % to about 40 wt. %, based on the total weight of the lyophilized dosage form, and at least one polymeric mucoadhesive matrix forming agent. The dosage form can have a pH of about 4.0 to 5.0, and can disintegrate within 120 seconds after being contacted with a vaginal mucosa. A method of delivering an active ingredient to the vaginal mucosa using the disclosed solid dosage form is also described.
