Christoph Rader,Thomas Hofer,Terrence R. Burke, JR.,Joshua Thomas
申请号：
US14579180
公开号：
US20150104383A1
申请日:
2014.12.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides methods and compositions employing hybrid molecules of a synthetic molecule and antibody or antibody fragment comprising a selenocysteine residue, wherein the synthetic molecule is covalently linked to the antibody or antibody fragment at the selenocysteine residue. The invention also provides a composition comprising a hybrid molecule as described above and a pharmaceutically acceptable carrier. The invention further provides for methods of making the hybrid molecules, and methods of using the hybrid molecule described above to inhibit cell surface receptor binding.
