Pro Drugs derived from (e) - n-methyl-n - ((3 - metilbenzofuran - 2 - yl) methyl) - 3 - (4 - oxo - 5,6,7,8-tetrahydro - 1.8 - naftiridin - 3 - il) acrylamide； Pharmaceutical composition that comprises； and its use to treat a bacterial infection.
PARTRIDGE JOHN J.,COLUCCI JOHN,GAREAU YVES,THERIEN MICHEL,ZAMBONI ROBERT,HAFKIN BARRY,MARFAT ANTHONY,ZAGHDANE HELMI
申请号：
CL2014003472
公开号：
CL2014003472A1
申请日:
2014.12.19
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
In part, the present disclosure is directed to prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide compounds with significant solubility and bioavailability profiles.COMPUESTOS DERIVADOS DE (E)-N-METIL-N-((3-METILBENZOFURAN-2-IL)METIL)-3-(7-OXO-5,6,7,8-TETRAHIDRO-1,8-NAFTIRIDIN-3-IL)-ACRILAMIDA, INHIBIDORES DEL METABOLISMO DE ÁCIDOS GRASOS BACTERIALES； COMPUESTOS INTERMEDIARIOS； PROCEDIMIENTO DE PREPARACIÓN； COMPOSICIONES FARMACOLÓGICAS Y SUS USOS； KIT FARMACÉUTICO； ÚTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS.
