ZIPKIN ROBERT ELLIOT,ADAMS JEFFREY KROLL,SPIEGEL SARAH
申请号:
IN4401/KOLNP/2011
公开号:
IN2011KN04401A
申请日:
2011.10.25
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
Provided are novel compositions which uniquely inhibit sphingosine kinase Type 1 (SphK1) and which are useful in a number of applications including killing or damaging cancer cells, inducing apoptosis, inhibiting growth, metastasis and development of chemoresistance in cancer cells, leukemia, increasing the effectiveness of anti-cancer agents, attenuating immune reactivity, inhibiting survival signaling in cancer cells, and reducing symptoms of multiple sclerosis.