J. Silvio Gutkind,Vyomesh Patel,Alfredo Molinolo,Timothy D. Veenstra
申请号：
US13376984
公开号：
US20120087892A1
申请日:
2010.06.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed herein is a method of detecting metastasis of a tumor in a subject, such as metastasis to a lymph node. The method includes directly determining an amount of desmoglein-3 (DSG-3) protein in a sample from the subject (such as a lymph node sample) and comparing the amount of DSG-3 protein to a control, wherein an increase in the amount of DSG-3 protein in the sample relative to the control indicates metastasis of the tumor to the lymph node. The disclosed methods further include selecting a therapy (for example, surgery, lymph node dissection, radiation therapy, chemotherapy, or a combination of two or more thereof) for the subject based on the amount of DSG-3 protein in the sample from the subject.
