METHOD OF MANUFACTURING GRANULES OR TABLETS FORMED AFTER PELLETIZING MULBERRY TWIGS, MULBERRY LEAVES AND RED-SEPALED EVENING PRIMROSE BY IONIZED DEXTRIN, AND BIOACTIVITY
PROBLEM TO BE SOLVED: To provide ideal functional food by which a longer life-span and the elongating effect of a healthy life-span are expected.SOLUTION: As a result of manufacturing mulberry leaf fine powder, mulberry twig fine powder and red-sepaled evening primrose (Oenothera erythrosepala) fine powder under thorough quality control, and formulating them by ionized dextrin, an effect of suppressing an increase of blood sugar level after loading glucose exhibited the same effect as a target drug (Basen), and usefulness as diabetes prevention and diabetes therapeutic agent was recognized. β-sitosterol glycoside selectively contained in red-sepaled evening primrose, and furthermore, 1-deoxynojirimycin contained only in mulberry and polyphenols being flavonoid-based polyphenol such as resveratrol and quercetin and phenol-based polyphenol such as chlorogenic acid, vitamin B1 which is essential in metabolizing glucide and lipid exhibit complex and synergistic preventive effects to vascular diseases derived from lifestyle-related diseases such as hypertension including diabetes.COPYRIGHT: (C)2014,JPO&INPIT【課題】長寿と健康寿命の延伸効果が期待される理想的な機能性食品の提供。【解決手段】桑葉微粉末、桑小枝微粉末およびオオマツヨイグサ微粉末を徹底した品質管理下で製造しイオン化デキストリンで製剤化した結果、糖負荷後の血糖値上昇抑制作用が対象薬物(ベイズイン)と同様の作用を示し糖尿病予防および糖尿病治療薬としての有用性が認められた。オオマツヨイグサに選択的に含有しているβ-シトステロール配糖体、さらに、桑のみが含有する1-デオキシノジリマイシンおよびレスベラトロール、ケルセチン等のフラボノイド系およびクロロゲン酸等のフェノール系のポリフェノール群、糖質、指質の代謝に必須のビタミンB1は、糖尿病を始めとする高血圧症等の生活習慣病から派生する血管疾患に複合的、相乗的な予防効果をも示す。【選択図】なし
