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RAPIDLY DISSOLVABLE MICRONEEDLES WITH DRUG-IMPREGNATED TIPS
专利权人:
LIM; Chee Yen
发明人:
CHIA, Yong Wei,LEE, Wei Siong
申请号:
SGSG2014/000058
公开号:
WO2015/122838A1
申请日:
2014.02.14
申请国别(地区):
WO
年份:
2015
代理人:
摘要:
The present invention relates to rapidly dissolvable microneedles comprising drug-impregnated tips, the medical use thereof. In the preferred embodiment, the rapidly dissolvable microneedle patch (10) comprises a plurality of microneedles or tiny spikes (20) which are disposed on a back layer (30). The microneedles (20) have tapered geometry and have two parts on each microneedle (20), namely the drug tip (22) and the needle body (24). The drug tip (22), which occupies only a fraction of the volume of the apex of the microneedle, contains active pharmaceutical ingredients which are impregnated into the microneedle by centrifuging. In practice, only a portion of the microneedle (20) will be inserted into the skin. The penetration line (26) is an imaginary line dividing the inserted portion (32) of the microneedle (20) (inserted into the skin) and the non-inserted portion (34) of the microneedle (20) when the microneedle (20) is inserted into the skin. The inserted portion (32) extends from the apex (28) of the microneedle to the penetration line (26), and the non- inserted portion (34) extends from the penetration line (26) to the base (29) of the microneedle. In this way, the drug tip (22) which stays within the inserted portion (32) of the microneedle (20) is guaranteed to be fully delivered to the skin.La présente invention concerne des micro-aiguilles à dissolution rapide, comprenant des pointes imprégnées dun médicament, et leur utilisation médicale. Dans le mode de réalisation préféré, le patch de micro-aiguille à dissolution rapide (10) comprend une pluralité de micro-aiguilles ou pointes minuscules (20) qui sont disposées sur une couche arrière (30). Les micro-aiguilles (20) ont une géométrie effilée et ont deux parties sur chaque micro-aiguille (20), cest-à-dire la pointe de médicament (22) et le corps daiguille (24). La pointe de médicament (22), qui occupe uniquement une fraction du volume du sommet de la micro-aiguille, contient des principes pharmaceutiq
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